| | Civilian Labor Force, 2021 | Persons Employed, 2021 | Persons Unemployed, 2021 | Unemployment Rate, 2021 | Unemployment Rate, Percent of U.S. Average, 2021 |
|
| United States | 161,204,000 | 152,581,000 | 8,623,000 | 5.3% | 100.0% |
| Appalachian Region | 12,010,661 | 11,455,917 | 554,744 | 4.6% | 86.3% |
| Alabama | 2,249,514 | 2,173,978 | 75,536 | 3.4% | 62.8% |
| Appalachian Alabama | 1,477,517 | 1,432,417 | 45,100 | 3.1% | 57.1% |
|
| County |
| Bibb | 8,604 | 8,312 | 292 | 3.4% | 63.4% |
| Blount | 25,268 | 24,674 | 594 | 2.4% | 43.9% |
| Calhoun | 46,166 | 44,307 | 1,859 | 4.0% | 75.3% |
| Chambers | 15,722 | 15,155 | 567 | 3.6% | 67.4% |
| Cherokee | 11,635 | 11,341 | 294 | 2.5% | 47.2% |
| Chilton | 19,918 | 19,360 | 558 | 2.8% | 52.4% |
| Clay | 6,021 | 5,858 | 163 | 2.7% | 50.6% |
| Cleburne | 5,888 | 5,737 | 151 | 2.6% | 47.9% |
| Colbert | 23,506 | 22,592 | 914 | 3.9% | 72.7% |
| Coosa | 4,352 | 4,220 | 132 | 3.0% | 56.7% |
| Cullman | 38,763 | 37,857 | 906 | 2.3% | 43.7% |
| DeKalb | 30,867 | 30,085 | 782 | 2.5% | 47.4% |
| Elmore | 37,708 | 36,702 | 1,006 | 2.7% | 49.9% |
| Etowah | 39,267 | 37,701 | 1,566 | 4.0% | 74.6% |
| Fayette | 6,612 | 6,411 | 201 | 3.0% | 56.8% |
| Franklin | 14,289 | 13,930 | 359 | 2.5% | 47.0% |
| Hale | 5,888 | 5,566 | 322 | 5.5% | 102.2% |
| Jackson | 22,972 | 22,319 | 653 | 2.8% | 53.1% |
| Jefferson | 318,929 | 307,640 | 11,289 | 3.5% | 66.2% |
| Lamar | 5,682 | 5,514 | 168 | 3.0% | 55.3% |
| Lauderdale | 42,181 | 40,869 | 1,312 | 3.1% | 58.1% |
| Lawrence | 14,441 | 14,025 | 416 | 2.9% | 53.9% |
| Limestone | 46,779 | 45,648 | 1,131 | 2.4% | 45.2% |
| Macon | 7,902 | 7,446 | 456 | 5.8% | 107.9% |
| Madison | 193,037 | 188,008 | 5,029 | 2.6% | 48.7% |
| Marion | 13,430 | 13,055 | 375 | 2.8% | 52.2% |
| Marshall | 44,704 | 43,644 | 1,060 | 2.4% | 44.3% |
| Morgan | 59,526 | 58,008 | 1,518 | 2.6% | 47.7% |
| Pickens | 7,513 | 7,211 | 302 | 4.0% | 75.1% |
| Randolph | 9,449 | 9,192 | 257 | 2.7% | 50.8% |
| Shelby | 118,888 | 116,385 | 2,503 | 2.1% | 39.4% |
| St. Clair | 41,422 | 40,350 | 1,072 | 2.6% | 48.4% |
| Talladega | 35,758 | 34,312 | 1,446 | 4.0% | 75.6% |
| Tallapoosa | 17,903 | 17,197 | 706 | 3.9% | 73.7% |
| Tuscaloosa | 101,242 | 97,672 | 3,570 | 3.5% | 65.9% |
| Walker | 25,213 | 24,318 | 895 | 3.5% | 66.4% |
| Winston | 10,072 | 9,796 | 276 | 2.7% | 51.2% |
