| | Civilian Labor Force, 2021 | Persons Employed, 2021 | Persons Unemployed, 2021 | Unemployment Rate, 2021 | Unemployment Rate, Percent of U.S. Average, 2021 |
|
| United States | 161,204,000 | 152,581,000 | 8,623,000 | 5.3% | 100.0% |
| Appalachian Region | 12,010,661 | 11,455,917 | 554,744 | 4.6% | 86.3% |
| Mississippi | 1,251,894 | 1,183,867 | 68,027 | 5.4% | 101.6% |
| Appalachian Mississippi | 267,685 | 253,798 | 13,887 | 5.2% | 97.0% |
|
| County |
| Alcorn | 15,096 | 14,386 | 710 | 4.7% | 87.9% |
| Benton | 3,031 | 2,841 | 190 | 6.3% | 117.2% |
| Calhoun | 5,434 | 5,155 | 279 | 5.1% | 96.0% |
| Chickasaw | 6,828 | 6,411 | 417 | 6.1% | 114.2% |
| Choctaw | 3,553 | 3,385 | 168 | 4.7% | 88.4% |
| Clay | 8,009 | 7,461 | 548 | 6.8% | 127.9% |
| Itawamba | 10,342 | 9,904 | 438 | 4.2% | 79.2% |
| Kemper | 3,273 | 3,037 | 236 | 7.2% | 134.8% |
| Lee | 41,259 | 39,399 | 1,860 | 4.5% | 84.3% |
| Lowndes | 24,633 | 23,212 | 1,421 | 5.8% | 107.8% |
| Marshall | 14,176 | 13,368 | 808 | 5.7% | 106.6% |
| Monroe | 15,749 | 14,948 | 801 | 5.1% | 95.1% |
| Montgomery | 3,851 | 3,621 | 230 | 6.0% | 111.7% |
| Noxubee | 3,586 | 3,281 | 305 | 8.5% | 159.0% |
| Oktibbeha | 22,276 | 21,066 | 1,210 | 5.4% | 101.5% |
| Panola | 12,489 | 11,630 | 859 | 6.9% | 128.6% |
| Pontotoc | 15,026 | 14,372 | 654 | 4.4% | 81.4% |
| Prentiss | 11,257 | 10,770 | 487 | 4.3% | 80.9% |
| Tippah | 9,412 | 8,985 | 427 | 4.5% | 84.8% |
| Tishomingo | 8,300 | 7,926 | 374 | 4.5% | 84.2% |
| Union | 14,095 | 13,533 | 562 | 4.0% | 74.5% |
| Webster | 3,904 | 3,696 | 208 | 5.3% | 99.6% |
| Winston | 7,219 | 6,787 | 432 | 6.0% | 111.9% |
| Yalobusha | 4,887 | 4,624 | 263 | 5.4% | 100.6% |
