| | Population Estimates Base, April 1, 2000 | Population Estimate, July 1, 2009 | Numeric Population Change, April 1, 2000 to July 1, 2009 | Percent Population Change, April 1, 2000 to July 1, 2009 |
|
| United States | 281,424,602 | 307,006,550 | 25,581,948 | 9.1% |
| Appalachian Region | 23,642,949 | 24,993,391 | 1,350,442 | 5.7% |
| Mississippi | 2,844,666 | 2,951,996 | 107,330 | 3.8% |
| Appalachian Mississippi | 615,453 | 623,260 | 7,807 | 1.3% |
|
| County |
| Alcorn | 34,558 | 35,822 | 1,264 | 3.7% |
| Benton | 8,026 | 7,981 | -45 | -0.6% |
| Calhoun | 15,069 | 14,422 | -647 | -4.3% |
| Chickasaw | 19,440 | 18,683 | -757 | -3.9% |
| Choctaw | 9,758 | 9,023 | -735 | -7.5% |
| Clay | 21,979 | 20,722 | -1,257 | -5.7% |
| Itawamba | 22,770 | 23,000 | 230 | 1.0% |
| Kemper | 10,453 | 9,833 | -620 | -5.9% |
| Lee | 75,755 | 81,913 | 6,158 | 8.1% |
| Lowndes | 61,586 | 59,658 | -1,928 | -3.1% |
| Marshall | 34,993 | 36,900 | 1,907 | 5.4% |
| Monroe | 38,014 | 36,905 | -1,109 | -2.9% |
| Montgomery | 12,189 | 11,129 | -1,060 | -8.7% |
| Noxubee | 12,548 | 11,631 | -917 | -7.3% |
| Oktibbeha | 42,899 | 44,544 | 1,645 | 3.8% |
| Panola | 34,280 | 35,245 | 965 | 2.8% |
| Pontotoc | 26,726 | 29,248 | 2,522 | 9.4% |
| Prentiss | 25,556 | 25,709 | 153 | 0.6% |
| Tippah | 20,826 | 21,661 | 835 | 4.0% |
| Tishomingo | 19,163 | 19,034 | -129 | -0.7% |
| Union | 25,362 | 27,263 | 1,901 | 7.5% |
| Webster | 10,294 | 9,852 | -442 | -4.3% |
| Winston | 20,160 | 19,309 | -851 | -4.2% |
| Yalobusha | 13,049 | 13,773 | 724 | 5.5% |
