| | Civilian Labor Force, 2021 | Persons Employed, 2021 | Persons Unemployed, 2021 | Unemployment Rate, 2021 | Unemployment Rate, Percent of U.S. Average, 2021 |
|
| United States | 161,204,000 | 152,581,000 | 8,623,000 | 5.3% | 100.0% |
| Appalachian Region | 12,010,661 | 11,455,917 | 554,744 | 4.6% | 86.3% |
| North Carolina | 4,939,281 | 4,697,757 | 241,524 | 4.9% | 91.4% |
| Appalachian North Carolina | 934,330 | 890,766 | 43,564 | 4.7% | 87.2% |
|
| County |
| Alexander | 17,320 | 16,577 | 743 | 4.3% | 80.2% |
| Alleghany | 4,213 | 4,013 | 200 | 4.7% | 88.7% |
| Ashe | 12,551 | 12,039 | 512 | 4.1% | 76.3% |
| Avery | 7,325 | 7,026 | 299 | 4.1% | 76.3% |
| Buncombe | 136,131 | 130,348 | 5,783 | 4.2% | 79.4% |
| Burke | 39,354 | 37,536 | 1,818 | 4.6% | 86.4% |
| Caldwell | 35,147 | 33,389 | 1,758 | 5.0% | 93.5% |
| Catawba | 76,606 | 72,986 | 3,620 | 4.7% | 88.3% |
| Cherokee | 10,553 | 10,013 | 540 | 5.1% | 95.7% |
| Clay | 3,945 | 3,744 | 201 | 5.1% | 95.3% |
| Cleveland | 47,529 | 44,980 | 2,549 | 5.4% | 100.3% |
| Davie | 19,998 | 19,121 | 877 | 4.4% | 82.0% |
| Forsyth | 182,288 | 173,169 | 9,119 | 5.0% | 93.5% |
| Graham | 2,997 | 2,789 | 208 | 6.9% | 129.7% |
| Haywood | 28,898 | 27,648 | 1,250 | 4.3% | 80.9% |
| Henderson | 53,056 | 50,850 | 2,206 | 4.2% | 77.7% |
| Jackson | 19,329 | 18,433 | 896 | 4.6% | 86.7% |
| Macon | 15,252 | 14,593 | 659 | 4.3% | 80.8% |
| Madison | 9,627 | 9,207 | 420 | 4.4% | 81.6% |
| McDowell | 19,844 | 18,930 | 914 | 4.6% | 86.1% |
| Mitchell | 5,886 | 5,577 | 309 | 5.2% | 98.1% |
| Polk | 9,008 | 8,578 | 430 | 4.8% | 89.2% |
| Rutherford | 23,961 | 22,403 | 1,558 | 6.5% | 121.6% |
| Stokes | 20,864 | 19,959 | 905 | 4.3% | 81.1% |
| Surry | 31,811 | 30,390 | 1,421 | 4.5% | 83.5% |
| Swain | 6,769 | 6,457 | 312 | 4.6% | 86.2% |
| Transylvania | 14,086 | 13,493 | 593 | 4.2% | 78.7% |
| Watauga | 28,110 | 27,041 | 1,069 | 3.8% | 71.1% |
| Wilkes | 26,941 | 25,634 | 1,307 | 4.9% | 90.7% |
| Yadkin | 16,974 | 16,237 | 737 | 4.3% | 81.2% |
| Yancey | 7,957 | 7,606 | 351 | 4.4% | 82.5% |