| | Civilian Labor Force, 2021 | Persons Employed, 2021 | Persons Unemployed, 2021 | Unemployment Rate, 2021 | Unemployment Rate, Percent of U.S. Average, 2021 |
|
| United States | 161,204,000 | 152,581,000 | 8,623,000 | 5.3% | 100.0% |
| Appalachian Region | 12,010,661 | 11,455,917 | 554,744 | 4.6% | 86.3% |
| Ohio | 5,708,982 | 5,415,608 | 293,374 | 5.1% | 96.1% |
| Appalachian Ohio | 868,577 | 820,043 | 48,534 | 5.6% | 104.5% |
|
| County |
| Adams | 10,897 | 10,202 | 695 | 6.4% | 119.2% |
| Ashtabula | 42,982 | 40,594 | 2,388 | 5.6% | 103.9% |
| Athens | 25,686 | 24,245 | 1,441 | 5.6% | 104.9% |
| Belmont | 27,667 | 25,955 | 1,712 | 6.2% | 115.7% |
| Brown | 19,296 | 18,256 | 1,040 | 5.4% | 100.8% |
| Carroll | 12,664 | 11,946 | 718 | 5.7% | 106.0% |
| Clermont | 106,598 | 101,943 | 4,655 | 4.4% | 81.6% |
| Columbiana | 45,490 | 42,852 | 2,638 | 5.8% | 108.4% |
| Coshocton | 13,703 | 12,896 | 807 | 5.9% | 110.1% |
| Gallia | 12,011 | 11,322 | 689 | 5.7% | 107.2% |
| Guernsey | 17,741 | 16,742 | 999 | 5.6% | 105.3% |
| Harrison | 6,464 | 6,060 | 404 | 6.3% | 116.8% |
| Highland | 17,209 | 16,215 | 994 | 5.8% | 108.0% |
| Hocking | 12,792 | 12,169 | 623 | 4.9% | 91.0% |
| Holmes | 21,303 | 20,700 | 603 | 2.8% | 52.9% |
| Jackson | 12,559 | 11,778 | 781 | 6.2% | 116.3% |
| Jefferson | 27,012 | 25,242 | 1,770 | 6.6% | 122.5% |
| Lawrence | 23,040 | 21,837 | 1,203 | 5.2% | 97.6% |
| Mahoning | 98,159 | 91,907 | 6,252 | 6.4% | 119.1% |
| Meigs | 8,730 | 8,148 | 582 | 6.7% | 124.6% |
| Monroe | 5,261 | 4,872 | 389 | 7.4% | 138.2% |
| Morgan | 6,716 | 6,295 | 421 | 6.3% | 117.2% |
| Muskingum | 40,313 | 38,231 | 2,082 | 5.2% | 96.6% |
| Noble | 4,605 | 4,292 | 313 | 6.8% | 127.1% |
| Perry | 15,817 | 14,928 | 889 | 5.6% | 105.1% |
| Pike | 10,818 | 10,130 | 688 | 6.4% | 118.9% |
| Ross | 34,917 | 33,207 | 1,710 | 4.9% | 91.6% |
| Scioto | 29,118 | 27,299 | 1,819 | 6.2% | 116.8% |
| Trumbull | 82,899 | 77,564 | 5,335 | 6.4% | 120.3% |
| Tuscarawas | 44,149 | 42,085 | 2,064 | 4.7% | 87.4% |
| Vinton | 5,461 | 5,120 | 341 | 6.2% | 116.7% |
| Washington | 26,500 | 25,011 | 1,489 | 5.6% | 105.0% |
