| | Civilian Labor Force, 2021 | Persons Employed, 2021 | Persons Unemployed, 2021 | Unemployment Rate, 2021 | Unemployment Rate, Percent of U.S. Average, 2021 |
|
| United States | 161,204,000 | 152,581,000 | 8,623,000 | 5.3% | 100.0% |
| Appalachian Region | 12,010,661 | 11,455,917 | 554,744 | 4.6% | 86.3% |
| Pennsylvania | 6,431,855 | 6,054,068 | 377,787 | 5.9% | 109.8% |
| Appalachian Pennsylvania | 2,743,672 | 2,576,089 | 167,583 | 6.1% | 114.2% |
|
| County |
| Allegheny | 633,043 | 597,285 | 35,758 | 5.6% | 105.6% |
| Armstrong | 31,356 | 29,150 | 2,206 | 7.0% | 131.5% |
| Beaver | 81,929 | 76,502 | 5,427 | 6.6% | 123.8% |
| Bedford | 23,857 | 22,536 | 1,321 | 5.5% | 103.5% |
| Blair | 59,370 | 56,054 | 3,316 | 5.6% | 104.4% |
| Bradford | 28,056 | 26,590 | 1,466 | 5.2% | 97.7% |
| Butler | 98,571 | 93,403 | 5,168 | 5.2% | 98.0% |
| Cambria | 55,758 | 52,107 | 3,651 | 6.5% | 122.4% |
| Cameron | 2,006 | 1,863 | 143 | 7.1% | 133.3% |
| Carbon | 32,108 | 30,102 | 2,006 | 6.2% | 116.8% |
| Centre | 76,497 | 73,190 | 3,307 | 4.3% | 80.8% |
| Clarion | 16,659 | 15,649 | 1,010 | 6.1% | 113.3% |
| Clearfield | 35,800 | 33,472 | 2,328 | 6.5% | 121.6% |
| Clinton | 17,290 | 16,213 | 1,077 | 6.2% | 116.4% |
| Columbia | 33,605 | 31,776 | 1,829 | 5.4% | 101.7% |
| Crawford | 38,003 | 35,654 | 2,349 | 6.2% | 115.6% |
| Elk | 14,931 | 13,982 | 949 | 6.4% | 118.8% |
| Erie | 126,713 | 118,159 | 8,554 | 6.8% | 126.2% |
| Fayette | 55,575 | 51,095 | 4,480 | 8.1% | 150.7% |
| Forest | 1,748 | 1,613 | 135 | 7.7% | 144.4% |
| Fulton | 7,131 | 6,715 | 416 | 5.8% | 109.1% |
| Greene | 15,768 | 14,703 | 1,065 | 6.8% | 126.3% |
| Huntingdon | 19,278 | 17,969 | 1,309 | 6.8% | 126.9% |
| Indiana | 37,467 | 35,006 | 2,461 | 6.6% | 122.8% |
| Jefferson | 19,732 | 18,532 | 1,200 | 6.1% | 113.7% |
| Juniata | 12,575 | 11,984 | 591 | 4.7% | 87.9% |
| Lackawanna | 103,684 | 97,124 | 6,560 | 6.3% | 118.3% |
| Lawrence | 39,709 | 36,914 | 2,795 | 7.0% | 131.6% |
| Luzerne | 157,240 | 145,327 | 11,913 | 7.6% | 141.6% |
| Lycoming | 55,517 | 52,057 | 3,460 | 6.2% | 116.5% |
| McKean | 17,046 | 15,952 | 1,094 | 6.4% | 120.0% |
| Mercer | 48,119 | 44,953 | 3,166 | 6.6% | 123.0% |
| Mifflin | 21,034 | 19,845 | 1,189 | 5.7% | 105.7% |
| Monroe | 81,994 | 76,201 | 5,793 | 7.1% | 132.1% |
| Montour | 9,103 | 8,732 | 371 | 4.1% | 76.2% |
| Northumberland | 42,370 | 39,714 | 2,656 | 6.3% | 117.2% |
| Perry | 24,240 | 23,174 | 1,066 | 4.4% | 82.2% |
| Pike | 25,290 | 23,584 | 1,706 | 6.7% | 126.1% |
| Potter | 7,099 | 6,644 | 455 | 6.4% | 119.8% |
| Schuylkill | 65,640 | 61,529 | 4,111 | 6.3% | 117.1% |
| Snyder | 19,699 | 18,744 | 955 | 4.8% | 90.6% |
| Somerset | 32,766 | 30,712 | 2,054 | 6.3% | 117.2% |
| Sullivan | 2,569 | 2,392 | 177 | 6.9% | 128.8% |
| Susquehanna | 20,107 | 19,080 | 1,027 | 5.1% | 95.5% |
| Tioga | 18,986 | 17,817 | 1,169 | 6.2% | 115.1% |
| Union | 19,604 | 18,743 | 861 | 4.4% | 82.1% |
| Venango | 21,990 | 20,595 | 1,395 | 6.3% | 118.6% |
| Warren | 18,109 | 16,976 | 1,133 | 6.3% | 117.0% |
| Washington | 105,114 | 98,656 | 6,458 | 6.1% | 114.9% |
| Wayne | 22,536 | 21,155 | 1,381 | 6.1% | 114.6% |
| Westmoreland | 176,003 | 165,668 | 10,335 | 5.9% | 109.8% |
| Wyoming | 13,278 | 12,497 | 781 | 5.9% | 110.0% |
