| | Civilian Labor Force, 2021 | Persons Employed, 2021 | Persons Unemployed, 2021 | Unemployment Rate, 2021 | Unemployment Rate, Percent of U.S. Average, 2021 |
|
| United States | 161,204,000 | 152,581,000 | 8,623,000 | 5.3% | 100.0% |
| Appalachian Region | 12,010,661 | 11,455,917 | 554,744 | 4.6% | 86.3% |
| South Carolina | 2,359,169 | 2,266,611 | 92,558 | 3.9% | 73.3% |
| Appalachian South Carolina | 627,901 | 604,870 | 23,031 | 3.7% | 68.6% |
|
| County |
| Anderson | 90,053 | 86,763 | 3,290 | 3.7% | 68.3% |
| Cherokee | 24,743 | 23,526 | 1,217 | 4.9% | 92.0% |
| Greenville | 255,636 | 247,052 | 8,584 | 3.4% | 62.8% |
| Oconee | 34,032 | 32,809 | 1,223 | 3.6% | 67.2% |
| Pickens | 56,865 | 54,913 | 1,952 | 3.4% | 64.2% |
| Spartanburg | 155,207 | 149,151 | 6,056 | 3.9% | 72.9% |
| Union | 11,365 | 10,656 | 709 | 6.2% | 116.6% |
