| | Civilian Labor Force, 2021 | Persons Employed, 2021 | Persons Unemployed, 2021 | Unemployment Rate, 2021 | Unemployment Rate, Percent of U.S. Average, 2021 |
|
| United States | 161,204,000 | 152,581,000 | 8,623,000 | 5.3% | 100.0% |
| Appalachian Region | 12,010,661 | 11,455,917 | 554,744 | 4.6% | 86.3% |
| Tennessee | 3,321,355 | 3,172,858 | 148,497 | 4.5% | 83.6% |
| Appalachian Tennessee | 1,348,308 | 1,292,717 | 55,591 | 4.1% | 77.1% |
|
| County |
| Anderson | 34,749 | 33,350 | 1,399 | 4.0% | 75.3% |
| Bledsoe | 4,299 | 4,063 | 236 | 5.5% | 102.6% |
| Blount | 64,450 | 62,113 | 2,337 | 3.6% | 67.8% |
| Bradley | 50,657 | 48,488 | 2,169 | 4.3% | 80.0% |
| Campbell | 14,775 | 14,037 | 738 | 5.0% | 93.4% |
| Cannon | 6,646 | 6,409 | 237 | 3.6% | 66.7% |
| Carter | 24,085 | 23,025 | 1,060 | 4.4% | 82.3% |
| Claiborne | 12,750 | 12,200 | 550 | 4.3% | 80.6% |
| Clay | 2,752 | 2,601 | 151 | 5.5% | 102.6% |
| Cocke | 14,722 | 13,872 | 850 | 5.8% | 107.9% |
| Coffee | 25,204 | 24,127 | 1,077 | 4.3% | 79.9% |
| Cumberland | 22,771 | 21,643 | 1,128 | 5.0% | 92.6% |
| DeKalb | 7,583 | 7,216 | 367 | 4.8% | 90.5% |
| Fentress | 7,541 | 7,223 | 318 | 4.2% | 78.8% |
| Franklin | 19,422 | 18,635 | 787 | 4.1% | 75.8% |
| Grainger | 9,588 | 9,163 | 425 | 4.4% | 82.9% |
| Greene | 28,843 | 27,520 | 1,323 | 4.6% | 85.8% |
| Grundy | 4,985 | 4,700 | 285 | 5.7% | 106.9% |
| Hamblen | 27,832 | 26,661 | 1,171 | 4.2% | 78.7% |
| Hamilton | 181,768 | 174,011 | 7,757 | 4.3% | 79.8% |
| Hancock | 2,259 | 2,145 | 114 | 5.0% | 94.3% |
| Hawkins | 23,070 | 21,995 | 1,075 | 4.7% | 87.1% |
| Jackson | 4,778 | 4,561 | 217 | 4.5% | 84.9% |
| Jefferson | 24,768 | 23,699 | 1,069 | 4.3% | 80.7% |
| Johnson | 7,697 | 7,411 | 286 | 3.7% | 69.5% |
| Knox | 246,772 | 238,320 | 8,452 | 3.4% | 64.0% |
| Lawrence | 19,315 | 18,445 | 870 | 4.5% | 84.2% |
| Lewis | 5,542 | 5,267 | 275 | 5.0% | 92.8% |
| Loudon | 23,920 | 23,062 | 858 | 3.6% | 67.1% |
| Macon | 11,331 | 10,896 | 435 | 3.8% | 71.8% |
| Marion | 12,172 | 11,616 | 556 | 4.6% | 85.4% |
| McMinn | 22,508 | 21,438 | 1,070 | 4.8% | 88.9% |
| Meigs | 5,161 | 4,899 | 262 | 5.1% | 94.9% |
| Monroe | 20,664 | 19,842 | 822 | 4.0% | 74.4% |
| Morgan | 7,718 | 7,368 | 350 | 4.5% | 84.8% |
| Overton | 9,971 | 9,594 | 377 | 3.8% | 70.7% |
| Pickett | 2,235 | 2,147 | 88 | 3.9% | 73.6% |
| Polk | 7,099 | 6,792 | 307 | 4.3% | 80.8% |
| Putnam | 35,454 | 34,072 | 1,382 | 3.9% | 72.9% |
| Rhea | 13,530 | 12,850 | 680 | 5.0% | 94.0% |
| Roane | 23,332 | 22,362 | 970 | 4.2% | 77.7% |
| Scott | 8,040 | 7,613 | 427 | 5.3% | 99.3% |
| Sequatchie | 6,115 | 5,829 | 286 | 4.7% | 87.4% |
| Sevier | 54,750 | 52,515 | 2,235 | 4.1% | 76.3% |
| Smith | 9,456 | 9,124 | 332 | 3.5% | 65.6% |
| Sullivan | 68,662 | 65,625 | 3,037 | 4.4% | 82.7% |
| Unicoi | 7,059 | 6,699 | 360 | 5.1% | 95.3% |
| Union | 7,739 | 7,412 | 327 | 4.2% | 79.0% |
| Van Buren | 2,018 | 1,914 | 104 | 5.2% | 96.3% |
| Warren | 16,713 | 15,883 | 830 | 5.0% | 92.8% |
| Washington | 61,140 | 58,854 | 2,286 | 3.7% | 69.9% |
| White | 11,898 | 11,411 | 487 | 4.1% | 76.5% |
