| | Civilian Labor Force, 2021 | Persons Employed, 2021 | Persons Unemployed, 2021 | Unemployment Rate, 2021 | Unemployment Rate, Percent of U.S. Average, 2021 |
|
| United States | 161,204,000 | 152,581,000 | 8,623,000 | 5.3% | 100.0% |
| Appalachian Region | 12,010,661 | 11,455,917 | 554,744 | 4.6% | 86.3% |
| Virginia | 4,315,045 | 4,148,175 | 166,870 | 3.9% | 72.3% |
| Appalachian Virginia | 327,662 | 314,468 | 13,194 | 4.0% | 75.3% |
|
| County |
| Alleghany (+ Covington city) | 8,839 | 8,440 | 399 | 4.5% | 84.4% |
| Bath | 2,244 | 2,145 | 99 | 4.4% | 82.5% |
| Bland | 2,741 | 2,647 | 94 | 3.4% | 64.1% |
| Botetourt | 17,171 | 16,652 | 519 | 3.0% | 56.5% |
| Buchanan | 6,145 | 5,739 | 406 | 6.6% | 123.5% |
| Carroll (+ Galax city) | 15,570 | 14,928 | 642 | 4.1% | 77.1% |
| Craig | 2,248 | 2,174 | 74 | 3.3% | 61.5% |
| Dickenson | 4,652 | 4,406 | 246 | 5.3% | 98.9% |
| Floyd | 8,216 | 7,960 | 256 | 3.1% | 58.3% |
| Giles | 7,797 | 7,528 | 269 | 3.5% | 64.5% |
| Grayson | 7,740 | 7,478 | 262 | 3.4% | 63.3% |
| Henry (+ Martinsville city) | 29,069 | 27,573 | 1,496 | 5.1% | 96.2% |
| Highland | 1,237 | 1,201 | 36 | 2.9% | 54.4% |
| Lee | 8,058 | 7,729 | 329 | 4.1% | 76.3% |
| Montgomery (+ Radford city) | 58,299 | 56,460 | 1,839 | 3.2% | 59.0% |
| Patrick | 7,115 | 6,799 | 316 | 4.4% | 83.0% |
| Pulaski | 16,039 | 15,407 | 632 | 3.9% | 73.7% |
| Rockbridge (+ Buena Vista city + Lexington city) | 15,546 | 14,940 | 606 | 3.9% | 72.9% |
| Russell | 10,731 | 10,266 | 465 | 4.3% | 81.0% |
| Scott | 8,875 | 8,557 | 318 | 3.6% | 67.0% |
| Smyth | 13,517 | 12,957 | 560 | 4.1% | 77.5% |
| Tazewell | 15,067 | 14,278 | 789 | 5.2% | 97.9% |
| Washington (+ Bristol city) | 32,860 | 31,606 | 1,254 | 3.8% | 71.3% |
| Wise (+ Norton city) | 14,298 | 13,557 | 741 | 5.2% | 96.9% |
| Wythe | 13,588 | 13,041 | 547 | 4.0% | 75.3% |
