| | Population Estimates Base, April 1, 2000 | Population Estimate, July 1, 2009 | Numeric Population Change, April 1, 2000 to July 1, 2009 | Percent Population Change, April 1, 2000 to July 1, 2009 |
|
| United States | 281,424,602 | 307,006,550 | 25,581,948 | 9.1% |
| Appalachian Region | 23,642,949 | 24,993,391 | 1,350,442 | 5.7% |
| Virginia | 7,079,048 | 7,882,590 | 803,542 | 11.4% |
| Appalachian Virginia | 757,932 | 760,060 | 2,128 | 0.3% |
|
| County |
| Alleghany (+ Covington city) | 23,518 | 22,391 | -1,127 | -4.8% |
| Bath | 5,048 | 4,482 | -566 | -11.2% |
| Bland | 6,871 | 6,791 | -80 | -1.2% |
| Botetourt | 30,496 | 32,551 | 2,055 | 6.7% |
| Buchanan | 26,978 | 22,860 | -4,118 | -15.3% |
| Carroll (+ Galax city) | 36,082 | 35,914 | -168 | -0.5% |
| Craig | 5,088 | 4,969 | -119 | -2.3% |
| Dickenson | 16,395 | 16,087 | -308 | -1.9% |
| Floyd | 13,874 | 15,013 | 1,139 | 8.2% |
| Giles | 16,657 | 17,358 | 701 | 4.2% |
| Grayson | 16,881 | 15,793 | -1,088 | -6.4% |
| Henry (+ Martinsville city) | 73,349 | 69,523 | -3,826 | -5.2% |
| Highland | 2,536 | 2,338 | -198 | -7.8% |
| Lee | 23,589 | 25,166 | 1,577 | 6.7% |
| Montgomery (+ Radford city) | 99,490 | 107,207 | 7,717 | 7.8% |
| Patrick | 19,407 | 18,636 | -771 | -4.0% |
| Pulaski | 35,127 | 35,022 | -105 | -0.3% |
| Rockbridge (+ Buena Vista city + Lexington city) | 34,024 | 34,417 | 393 | 1.2% |
| Russell | 29,258 | 29,250 | -8 | 0.0% |
| Scott | 23,403 | 22,585 | -818 | -3.5% |
| Smyth | 33,081 | 31,738 | -1,343 | -4.1% |
| Tazewell | 44,598 | 44,907 | 309 | 0.7% |
| Washington (+ Bristol city) | 68,470 | 70,708 | 2,238 | 3.3% |
| Wise (+ Norton city) | 46,113 | 45,486 | -627 | -1.4% |
| Wythe | 27,599 | 28,868 | 1,269 | 4.6% |
