| | Population, April 1, 2000 | Population, April 1, 2010 | Numeric Population Change, 2000 to 2010 | Percent Population Change, 2000 to 2010 | Land Area (square miles), 2010 | Persons Per Square Mile, 2010 |
|
| United States | 281,421,906 | 308,745,538 | 27,323,632 | 9.7% | 3,531,905.4 | 87.4 |
| Appalachian Region | 23,642,578 | 25,243,456 | 1,600,878 | 6.8% | 204,452.1 | 123.5 |
| South Carolina | 4,012,012 | 4,625,364 | 613,352 | 15.3% | 30,060.7 | 153.9 |
| Appalachian South Carolina | 1,028,656 | 1,171,497 | 142,841 | 13.9% | 3,823.9 | 306.4 |
|
| County |
| Anderson | 165,740 | 187,126 | 21,386 | 12.9% | 715.4 | 261.6 |
| Cherokee | 52,537 | 55,342 | 2,805 | 5.3% | 392.7 | 140.9 |
| Greenville | 379,616 | 451,225 | 71,609 | 18.9% | 785.1 | 574.7 |
| Oconee | 66,215 | 74,273 | 8,058 | 12.2% | 626.3 | 118.6 |
| Pickens | 110,757 | 119,224 | 8,467 | 7.6% | 496.4 | 240.2 |
| Spartanburg | 253,791 | 284,307 | 30,516 | 12.0% | 807.9 | 351.9 |
